MIGRAINE
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Naproxen 500 mg Domperidon 10 mg Tablets
Introduction
Naproxen + Domperidone is a combination therapy belonging to the group of analgesics used for the treatment of migraine headaches, rheumatoid arthritis, gout, and dysmenorrhea (menstrual pain). It also helps in controlling nausea and vomiting associated with migraines.
Mechanism of Action
- Naproxen: A non-steroidal anti-inflammatory drug (NSAID) that blocks cyclooxygenase (COX) enzymes, reducing prostaglandin production responsible for pain and inflammation.
- Domperidone: An antiemetic that blocks dopamine receptors in the brain’s vomiting center (chemoreceptor trigger zone) to prevent nausea and vomiting.
Uses
- Treatment of Migraine headaches
- Pain relief in rheumatoid arthritis, gout, and menstrual cramps (dysmenorrhea)
- Inflammation reduction in joint disorders
- Fever management
- Relief of muscle pain
- Control of nausea and vomiting associated with migraine
Medicinal Benefits
- Pain and Inflammation Relief: Naproxen reduces pain, swelling, and inflammation effectively.
- Nausea and Vomiting Control: Domperidone enhances stomach emptying and prevents vomiting.
- Multi-Symptom Management: Addresses both pain and gastric symptoms simultaneously for better patient comfort and recovery.
Dosage and Administration
- Take with food to minimize stomach irritation.
- Swallow the tablet whole with a glass of water.
- Do not crush, chew, or break the tablet.
- Always follow your doctor’s dosage and timing instructions.
Storage
Store in a cool, dry place, away from direct sunlight and moisture.
Warnings and Precautions
- Inform your doctor if you have:
- History of allergies to medicines or foods
- Heart rhythm problems, ulcers, gastrointestinal bleeding, or stroke history
- Pre-existing conditions like asthma, liver disease, kidney disease, or bleeding disorders
- Pregnancy and Breastfeeding: Use only after medical consultation.
- Elderly patients (above 65 years) should use with caution under medical supervision.